PHB1

PHB1

prohibitin 1 | BAP32, PHB

This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Member of: DE-1 Developmental clusters: GC4

Biological processes 79 terms

B cell activation (GO:0042113)B cell activation (GO:0042113)RIG-I signaling pathway (GO:0039529)RIG-I signaling pathway (GO:0039529)T-helper 17 type immune response (GO:0072538)antiviral innate immune response (GO:0140374)antiviral innate immune response (GO:0140374)cell surface (GO:0009986)cell surface (GO:0009986)cellular response to interleukin-6 (GO:0071354)complement component C3a binding (GO:0001850)complement component C3b binding (GO:0001851)cytoplasm (GO:0005737)cytoplasm (GO:0005737)early endosome (GO:0005769)enzyme binding (GO:0019899)epigenetic regulation of gene expression (GO:0040029)extracellular exosome (GO:0070062)histone deacetylase binding (GO:0042826)host-mediated perturbation of viral RNA genome replication (GO:0044830)host-mediated perturbation of viral RNA genome replication (GO:0044830)membrane (GO:0016020)membrane (GO:0016020)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrial prohibitin complex (GO:0035632)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion organization (GO:0007005)mitochondrion organization (GO:0007005)mitochondrion organization (GO:0007005)mitochondrion organization (GO:0007005)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of ERK1 and ERK2 cascade (GO:0070373)negative regulation of androgen receptor signaling pathway (GO:0060766)negative regulation of androgen receptor signaling pathway (GO:0060766)negative regulation of cell growth (GO:0030308)negative regulation of cell population proliferation (GO:0008285)negative regulation of nuclear receptor-mediated glucocorticoid signaling pathway (GO:2000323)negative regulation of protein catabolic process (GO:0042177)negative regulation of transcription by RNA polymerase II (GO:0000122)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)osteoblast differentiation (GO:0001649)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of ERK1 and ERK2 cascade (GO:0070374)positive regulation of G protein-coupled receptor signaling pathway (GO:0045745)positive regulation of complement activation (GO:0045917)positive regulation of gene expression (GO:0010628)positive regulation of immunoglobulin production (GO:0002639)positive regulation of immunoglobulin production (GO:0002639)positive regulation of interleukin-17 production (GO:0032740)positive regulation of neuron apoptotic process (GO:0043525)positive regulation of non-canonical NF-kappaB signal transduction (GO:1901224)positive regulation of non-canonical NF-kappaB signal transduction (GO:1901224)positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0051897)positive regulation of smooth muscle cell proliferation (GO:0048661)progesterone receptor signaling pathway (GO:0050847)protein binding (GO:0005515)protein heterodimerization activity (GO:0046982)protein stabilization (GO:0050821)protein stabilization (GO:0050821)proteinase activated receptor binding (GO:0031871)regulation of DNA-templated transcription (GO:0006355)regulation of apoptotic process (GO:0042981)signal transduction (GO:0007165)symbiont entry into host cell (GO:0046718)symbiont entry into host cell (GO:0046718)transcription corepressor activity (GO:0003714)transcription corepressor activity (GO:0003714)

Expression (TPM)

TFs regulating PHB1 0 TFs

Transcription factors with Perturb-seq knockdown data for PHB1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PHB1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to PHB1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PHB1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility	Element	Dist. to TSS	Link type	TFs
	chr17:49,191,794–49,193,465	222.1 kb	Distal (>10kb) Multiome	1177
	chr17:49,223,535–49,224,633	191.1 kb	Distal (>10kb) Multiome	281
	chr17:49,230,380–49,231,209	184.0 kb	Distal (>10kb) Multiome	496
	chr17:49,260,115–49,260,840	154.4 kb	Distal (>10kb) Multiome	480
	chr17:49,361,317–49,363,214	52.5 kb	Distal (>10kb) Multiome	873
	chr17:49,371,314–49,372,084	43.2 kb	Distal (>10kb) Multiome	235
	chr17:49,408,077–49,408,297	6.6 kb	Proximal (<10kb)	466
	chr17:49,414,619–49,415,442	151 bp	At TSS Multiome	829
	chr17:49,486,189–49,486,812	71.6 kb	Distal (>10kb) Multiome	147
	chr17:49,494,780–49,495,773	80.4 kb	Distal (>10kb) Multiome	386
	chr17:49,496,269–49,496,902	81.7 kb	Distal (>10kb) Multiome	440
	chr17:49,497,462–49,497,966	83.0 kb	Distal (>10kb) Multiome	280
	chr17:49,508,179–49,508,962	93.7 kb	Distal (>10kb) Multiome	380
	chr17:49,556,195–49,556,772	141.6 kb	Distal (>10kb) Multiome HiCAR	636
	chr17:49,567,907–49,568,549	153.3 kb	Distal (>10kb) Multiome	623
	chr17:49,569,780–49,570,501	155.3 kb	Distal (>10kb) Multiome	893
	chr17:49,575,427–49,577,397	161.8 kb	Distal (>10kb) Multiome	657
	chr17:49,677,242–49,678,492	263.2 kb	Distal (>10kb) Multiome	1110
	chr17:49,707,638–49,708,519	293.4 kb	Distal (>10kb) Multiome HiCAR	927

Genome Browser

Genomic view of the PHB1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.