Predicted to enable zinc ion binding activity. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PDZRN4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PDZRN4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PDZRN4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:41,187,936–41,189,264 | 258 bp | At TSS Multiome | 298 | |
| chr12:41,189,404–41,190,400 | 1.1 kb | Proximal (<10kb) | 174 | |
| chr12:41,190,512–41,190,674 | 2.2 kb | Proximal (<10kb) | 57 | |
| chr12:41,333,999–41,334,953 | 146.2 kb | Distal (>10kb) Multiome | 108 | |
| chr12:41,365,399–41,366,183 | 177.5 kb | Distal (>10kb) Multiome | 237 |
Genomic view of the PDZRN4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.