This gene contains coding mononucleotide repeats that are associated with tumors of high mcrosatellite instability (MSI-H). Defects in this gene are involved in the tumorigenesis of MSI-H colorectal carcinomas. [provided by RefSeq, Jun 2016]
Transcription factors with Perturb-seq knockdown data for PCNX2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PCNX2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PCNX2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:232,629,319–232,630,977 | 665.4 kb | Distal (>10kb) Multiome HiCAR | 598 | |
| chr1:233,228,052–233,228,602 | 67.4 kb | Distal (>10kb) Multiome | 34 | |
| chr1:233,233,376–233,234,177 | 61.9 kb | Distal (>10kb) Multiome | 143 | |
| chr1:233,289,493–233,290,196 | 5.9 kb | Proximal (<10kb) Multiome | 155 | |
| chr1:233,294,969–233,295,863 | 111 bp | At TSS Multiome | 466 | |
| chr1:233,326,831–233,329,042 | 31.8 kb | Distal (>10kb) Multiome | 601 | |
| chr1:233,471,138–233,474,579 | 176.1 kb | Distal (>10kb) Multiome | 432 | |
| chr1:233,587,899–233,588,712 | 292.6 kb | Distal (>10kb) Multiome | 287 | |
| chr1:234,075,263–234,075,988 | 780.1 kb | Distal (>10kb) Multiome HiCAR | 61 | |
| chr1:234,092,919–234,093,755 | 797.6 kb | Distal (>10kb) Multiome HiCAR | 62 | |
| chr1:234,261,272–234,262,769 | 966.2 kb | Distal (>10kb) Multiome HiCAR | 234 | |
| chr1:234,372,993–234,374,088 | 1077.8 kb | Distal (>10kb) Multiome HiCAR | 1034 |
Genomic view of the PCNX2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.