The protein encoded by this gene binds to CLP1 to form pre-mRNA cleavage factor IIm. The encoded protein is necessary for efficient Pol II transcription termination and may be involved in degradation of the 3' product of polyA site cleavage. [provided by RefSeq, Oct 2016]
Transcription factors with Perturb-seq knockdown data for PCF11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PCF11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PCF11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:82,899,722–82,902,187 | 278.7 kb | Distal (>10kb) Multiome HiCAR | 1001 | |
| chr11:82,970,431–82,971,628 | 209.6 kb | Distal (>10kb) Multiome | 188 | |
| chr11:83,034,012–83,034,897 | 145.9 kb | Distal (>10kb) Multiome | 343 | |
| chr11:83,071,319–83,072,558 | 108.5 kb | Distal (>10kb) Multiome | 943 | |
| chr11:83,144,373–83,145,287 | 35.6 kb | Distal (>10kb) Multiome | 76 | |
| chr11:83,156,155–83,158,430 | 23.5 kb | Distal (>10kb) Multiome | 1001 | |
| chr11:83,193,357–83,194,770 | 13.3 kb | Distal (>10kb) Multiome | 817 | |
| chr11:83,241,143–83,241,871 | 61.1 kb | Distal (>10kb) Multiome | 285 | |
| chr11:83,285,491–83,286,808 | 105.8 kb | Distal (>10kb) Multiome | 1057 | |
| chr11:83,318,271–83,319,586 | 138.5 kb | Distal (>10kb) Multiome | 190 | |
| chr11:83,443,851–83,444,454 | 263.6 kb | Distal (>10kb) Multiome | 56 |
Genomic view of the PCF11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.