This gene encodes a protein that belongs to the GDSL/SGNH-like acyl-esterase family. Members of this family are hydrolases thought to function in modification of biopolymers on the cell surface. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
Transcription factors with Perturb-seq knockdown data for PCED1B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PCED1B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PCED1B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:47,079,343–47,080,725 | 143.6 kb | Distal (>10kb) Multiome | 614 | |
| chr12:47,206,926–47,207,587 | 16.3 kb | Distal (>10kb) Multiome | 292 | |
| chr12:47,222,691–47,224,041 | 803 bp | At TSS Multiome | 414 | |
| chr12:47,231,367–47,231,618 | 7.8 kb | Proximal (<10kb) | 15 | |
| chr12:47,231,719–47,231,879 | 8.2 kb | Proximal (<10kb) | 26 | |
| chr12:47,249,264–47,250,499 | 26.4 kb | Distal (>10kb) Multiome | 235 | |
| chr12:47,286,476–47,287,027 | 63.3 kb | Distal (>10kb) Multiome | 67 |
Genomic view of the PCED1B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.