Transcription factors with Perturb-seq knockdown data for PCAT7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PCAT7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PCAT7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:94,259,139–94,259,781 | 295.8 kb | Distal (>10kb) Multiome | 663 | |
| chr9:94,374,230–94,375,026 | 180.6 kb | Distal (>10kb) Multiome | 332 | |
| chr9:94,552,994–94,555,388 | 236 bp | At TSS Multiome | 631 | |
| chr9:94,608,138–94,608,779 | 53.3 kb | Distal (>10kb) Multiome HiCAR | 331 | |
| chr9:94,639,019–94,639,691 | 84.3 kb | Distal (>10kb) Multiome | 277 | |
| chr9:94,639,882–94,640,360 | 85.1 kb | Distal (>10kb) Multiome | 156 | |
| chr9:94,696,327–94,696,930 | 141.6 kb | Distal (>10kb) Multiome | 18 | |
| chr9:94,726,305–94,727,294 | 171.6 kb | Distal (>10kb) Multiome | 856 | |
| chr9:94,746,310–94,746,827 | 191.5 kb | Distal (>10kb) Multiome | 82 | |
| chr9:95,127,363–95,127,907 | 572.6 kb | Distal (>10kb) Multiome HiCAR | 314 |
Genomic view of the PCAT7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.