Predicted to enable DNA binding activity. Involved in negative regulation of double-strand break repair via homologous recombination. Located in chromatin and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PARPBP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PARPBP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PARPBP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:101,830,071–101,831,573 | 289.3 kb | Distal (>10kb) Multiome | 637 | |
| chr12:101,876,810–101,878,266 | 242.7 kb | Distal (>10kb) Multiome | 1007 | |
| chr12:102,061,470–102,062,548 | 58.2 kb | Distal (>10kb) Multiome | 687 | |
| chr12:102,119,615–102,121,249 | 32 bp | At TSS Multiome | 891 | |
| chr12:102,154,546–102,155,516 | 34.7 kb | Distal (>10kb) Multiome | 90 |
Genomic view of the PARPBP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.