Enables kinase binding activity; pentosyltransferase activity; and protein serine/threonine kinase activator activity. Involved in IRE1-mediated unfolded protein response; negative regulation of cytoplasmic translation; and protein auto-ADP-ribosylation. Located in endoplasmic reticulum tubular network and nuclear envelope. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PARP16. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PARP16 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PARP16, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:64,989,345–64,990,371 | 297.0 kb | Distal (>10kb) Multiome | 859 | |
| chr15:65,028,915–65,029,974 | 257.3 kb | Distal (>10kb) Multiome | 703 | |
| chr15:65,049,359–65,049,794 | 237.3 kb | Distal (>10kb) Multiome | 267 | |
| chr15:65,067,081–65,068,384 | 218.8 kb | Distal (>10kb) Multiome | 131 | |
| chr15:65,101,638–65,102,425 | 185.0 kb | Distal (>10kb) Multiome | 204 | |
| chr15:65,132,889–65,133,960 | 153.1 kb | Distal (>10kb) Multiome | 775 | |
| chr15:65,184,434–65,185,938 | 101.4 kb | Distal (>10kb) Multiome HiCAR | 985 | |
| chr15:65,286,029–65,287,330 | 25 bp | At TSS Multiome | 919 | |
| chr15:65,289,512–65,289,739 | 2.6 kb | Proximal (<10kb) | 28 | |
| chr15:65,295,595–65,297,682 | 9.4 kb | Proximal (<10kb) Multiome | 1039 | |
| chr15:65,297,790–65,298,201 | 2.4 kb | Proximal (<10kb) | 336 | |
| chr15:65,299,879–65,301,676 | 14.1 kb | Distal (>10kb) Multiome | 464 | |
| chr15:65,303,709–65,305,825 | 18.0 kb | Distal (>10kb) Multiome | 1230 | |
| chr15:65,355,116–65,356,095 | 68.7 kb | Distal (>10kb) Multiome | 288 | |
| chr15:65,376,859–65,378,657 | 91.1 kb | Distal (>10kb) Multiome | 612 | |
| chr15:65,384,869–65,386,083 | 98.9 kb | Distal (>10kb) Multiome | 703 | |
| chr15:65,400,812–65,401,824 | 114.5 kb | Distal (>10kb) Multiome | 406 | |
| chr15:65,414,873–65,415,582 | 128.4 kb | Distal (>10kb) Multiome | 333 | |
| chr15:65,421,061–65,422,050 | 134.7 kb | Distal (>10kb) Multiome | 457 | |
| chr15:65,422,462–65,423,579 | 136.2 kb | Distal (>10kb) Multiome | 450 | |
| chr15:65,517,110–65,517,892 | 230.8 kb | Distal (>10kb) Multiome | 1031 | |
| chr15:65,521,411–65,521,886 | 234.7 kb | Distal (>10kb) Multiome | 35 | |
| chr15:65,530,109–65,531,265 | 243.6 kb | Distal (>10kb) Multiome | 922 |
Genomic view of the PARP16 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.