Predicted to be involved in centrosome cycle; establishment or maintenance of epithelial cell apical/basal polarity; and regulation of cellular localization. Predicted to be located in cytosol; plasma membrane; and tight junction. Predicted to be part of PAR polarity complex. Predicted to be active in apical plasma membrane; cell cortex; and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PARD6G. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PARD6G upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PARD6G, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:79,950,747–79,952,381 | 295.8 kb | Distal (>10kb) Multiome | 606 | |
| chr18:79,960,055–79,960,750 | 287.0 kb | Distal (>10kb) Multiome | 94 | |
| chr18:79,964,253–79,964,855 | 282.9 kb | Distal (>10kb) Multiome | 536 | |
| chr18:79,988,046–79,989,235 | 259.0 kb | Distal (>10kb) Multiome | 832 | |
| chr18:80,033,036–80,034,844 | 213.4 kb | Distal (>10kb) Multiome | 863 | |
| chr18:80,108,658–80,110,068 | 138.4 kb | Distal (>10kb) Multiome | 673 | |
| chr18:80,119,162–80,119,666 | 128.1 kb | Distal (>10kb) Multiome | 42 | |
| chr18:80,147,532–80,148,374 | 99.7 kb | Distal (>10kb) Multiome | 357 | |
| chr18:80,245,958–80,247,961 | 1.0 kb | Proximal (<10kb) Multiome | 405 |
Genomic view of the PARD6G locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.