The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PANX1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PANX1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PANX1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:93,849,777–93,850,638 | 278.6 kb | Distal (>10kb) Multiome | 277 | |
| chr11:93,871,397–93,872,351 | 257.0 kb | Distal (>10kb) Multiome | 72 | |
| chr11:93,903,808–93,904,283 | 224.8 kb | Distal (>10kb) Multiome | 40 | |
| chr11:93,907,116–93,907,874 | 221.3 kb | Distal (>10kb) Multiome | 41 | |
| chr11:94,128,241–94,129,803 | 43 bp | At TSS Multiome | 920 | |
| chr11:94,351,024–94,351,644 | 222.3 kb | Distal (>10kb) Multiome | 45 | |
| chr11:94,400,876–94,402,024 | 272.5 kb | Distal (>10kb) Multiome | 221 |
Genomic view of the PANX1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.