Contributes to poly(A)-specific ribonuclease activity. Predicted to be involved in nuclear-transcribed mRNA poly(A) tail shortening. Predicted to act upstream of or within deadenylation-dependent decapping of nuclear-transcribed mRNA; positive regulation of cytoplasmic mRNA processing body assembly; and protein targeting. Part of PAN complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PAN3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PAN3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PAN3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:27,919,827–27,920,448 | 218.5 kb | Distal (>10kb) Multiome | 287 | |
| chr13:27,953,483–27,954,867 | 184.5 kb | Distal (>10kb) Multiome | 490 | |
| chr13:27,960,317–27,961,430 | 177.9 kb | Distal (>10kb) Multiome | 665 | |
| chr13:27,965,744–27,967,347 | 172.4 kb | Distal (>10kb) Multiome | 344 | |
| chr13:27,968,317–27,969,555 | 169.7 kb | Distal (>10kb) Multiome | 369 | |
| chr13:27,978,000–27,978,930 | 160.0 kb | Distal (>10kb) Multiome | 128 | |
| chr13:28,100,058–28,101,151 | 38.0 kb | Distal (>10kb) Multiome | 417 | |
| chr13:28,137,740–28,140,378 | 369 bp | At TSS Multiome | 881 | |
| chr13:28,140,531–28,140,720 | 2.0 kb | Proximal (<10kb) | 60 | |
| chr13:28,141,465–28,142,148 | 3.2 kb | Proximal (<10kb) Multiome | 153 | |
| chr13:28,429,691–28,430,157 | 291.5 kb | Distal (>10kb) Multiome | 217 | |
| chr13:28,438,646–28,439,159 | 300.4 kb | Distal (>10kb) Multiome | 55 |
Genomic view of the PAN3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.