This gene encodes a member of the paralemmin protein family. The product of this gene is a prenylated and palmitoylated phosphoprotein that associates with the cytoplasmic face of plasma membranes and is implicated in plasma membrane dynamics in neurons and other cell types. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PALM. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PALM upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PALM, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:408,569–409,459 | 299.8 kb | Distal (>10kb) Multiome | 310 | |
| chr19:459,789–461,382 | 248.7 kb | Distal (>10kb) Multiome | 545 | |
| chr19:461,557–462,453 | 246.9 kb | Distal (>10kb) Multiome | 580 | |
| chr19:488,399–489,918 | 219.8 kb | Distal (>10kb) Multiome | 898 | |
| chr19:506,451–508,366 | 201.8 kb | Distal (>10kb) Multiome | 1001 | |
| chr19:510,509–511,797 | 198.0 kb | Distal (>10kb) Multiome | 739 | |
| chr19:518,865–519,356 | 189.8 kb | Distal (>10kb) Multiome | 151 | |
| chr19:530,809–533,397 | 177.5 kb | Distal (>10kb) Multiome | 856 | |
| chr19:572,071–573,594 | 136.5 kb | Distal (>10kb) Multiome | 888 | |
| chr19:588,127–589,976 | 120.6 kb | Distal (>10kb) Multiome | 526 | |
| chr19:632,653–633,806 | 75.3 kb | Distal (>10kb) Multiome | 758 | |
| chr19:639,456–640,331 | 69.1 kb | Distal (>10kb) Multiome | 389 | |
| chr19:662,267–663,864 | 45.6 kb | Distal (>10kb) Multiome | 723 | |
| chr19:679,616–681,731 | 28.2 kb | Distal (>10kb) Multiome | 832 | |
| chr19:703,387–704,718 | 4.9 kb | Proximal (<10kb) Multiome | 586 | |
| chr19:708,425–709,293 | 115 bp | At TSS Multiome | 317 | |
| chr19:796,668–798,362 | 88.3 kb | Distal (>10kb) Multiome | 956 | |
| chr19:821,294–822,728 | 113.2 kb | Distal (>10kb) Multiome | 254 | |
| chr19:861,664–863,223 | 153.3 kb | Distal (>10kb) Multiome | 530 | |
| chr19:892,703–893,746 | 184.3 kb | Distal (>10kb) Multiome | 715 | |
| chr19:917,038–918,169 | 208.9 kb | Distal (>10kb) Multiome | 711 | |
| chr19:924,743–926,242 | 216.8 kb | Distal (>10kb) Multiome | 796 | |
| chr19:927,058–927,629 | 218.4 kb | Distal (>10kb) Multiome | 362 | |
| chr19:982,565–983,215 | 273.9 kb | Distal (>10kb) Multiome | 590 | |
| chr19:984,046–985,154 | 275.6 kb | Distal (>10kb) Multiome | 829 | |
| chr19:1,000,142–1,000,881 | 291.4 kb | Distal (>10kb) Multiome | 399 |
Genomic view of the PALM locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.