Enables nuclear estrogen receptor binding activity. Involved in positive regulation of cell cycle G1/S phase transition; positive regulation of intracellular estrogen receptor signaling pathway; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of MLL3/4 complex. Biomarker of esophagus squamous cell carcinoma. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PAGR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PAGR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PAGR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:29,594,581–29,595,807 | 220.7 kb | Distal (>10kb) Multiome | 486 | |
| chr16:29,613,063–29,614,058 | 202.4 kb | Distal (>10kb) Multiome | 302 | |
| chr16:29,614,664–29,615,288 | 201.1 kb | Distal (>10kb) Multiome | 247 | |
| chr16:29,666,524–29,667,045 | 149.4 kb | Distal (>10kb) Multiome | 338 | |
| chr16:29,678,867–29,679,831 | 136.9 kb | Distal (>10kb) Multiome | 783 | |
| chr16:29,708,839–29,709,431 | 107.1 kb | Distal (>10kb) Multiome | 96 | |
| chr16:29,709,743–29,710,091 | 106.1 kb | Distal (>10kb) Multiome | 21 | |
| chr16:29,784,957–29,785,426 | 30.9 kb | Distal (>10kb) Multiome | 452 | |
| chr16:29,790,073–29,791,192 | 25.5 kb | Distal (>10kb) Multiome | 1003 | |
| chr16:29,804,592–29,808,172 | 10.3 kb | Distal (>10kb) Multiome | 1275 | |
| chr16:29,810,746–29,812,649 | 3.8 kb | Proximal (<10kb) Multiome | 826 | |
| chr16:29,815,828–29,817,186 | 1 bp | At TSS Multiome | 1006 | |
| chr16:29,862,597–29,863,901 | 47.3 kb | Distal (>10kb) Multiome | 953 | |
| chr16:29,876,281–29,878,282 | 61.5 kb | Distal (>10kb) Multiome | 319 | |
| chr16:29,899,174–29,900,833 | 83.3 kb | Distal (>10kb) Multiome | 1019 | |
| chr16:29,925,692–29,926,784 | 110.1 kb | Distal (>10kb) Multiome | 912 | |
| chr16:29,961,477–29,962,530 | 145.8 kb | Distal (>10kb) Multiome | 848 | |
| chr16:29,973,238–29,974,906 | 157.6 kb | Distal (>10kb) Multiome | 935 | |
| chr16:29,994,888–29,996,728 | 180.0 kb | Distal (>10kb) Multiome | 1080 | |
| chr16:30,021,215–30,021,860 | 205.4 kb | Distal (>10kb) Multiome HiCAR | 764 | |
| chr16:30,052,803–30,053,364 | 236.9 kb | Distal (>10kb) Multiome | 989 | |
| chr16:30,063,722–30,066,296 | 247.9 kb | Distal (>10kb) Multiome | 1209 | |
| chr16:30,075,490–30,076,439 | 259.8 kb | Distal (>10kb) Multiome | 828 | |
| chr16:30,090,881–30,092,910 | 276.7 kb | Distal (>10kb) Multiome | 1101 | |
| chr16:30,095,557–30,096,839 | 280.2 kb | Distal (>10kb) Multiome | 824 |
Genomic view of the PAGR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.