OSBPL8

oxysterol binding protein like 8 | MST120, MSTP120, ORP8, OSBP10

This gene encodes a member of a family of proteins containing an N-terminal pleckstrin homology domain and a highly conserved C-terminal oxysterol-binding protein-like sterol-binding domain. It binds mutliple lipid-containing molecules, including phosphatidylserine, phosphatidylinositol 4-phosphate (PI4P) and oxysterol, and promotes their exchange between the endoplasmic reticulum and the plasma membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Member of: DE-2 DE-2.8 Developmental clusters: GC4

Biological processes 33 terms

cholesterol binding (GO:0015485)cholesterol binding (GO:0015485)cholesterol binding (GO:0015485)cortical endoplasmic reticulum (GO:0032541)cytosol (GO:0005829)cytosol (GO:0005829)endomembrane system (GO:0012505)endoplasmic reticulum (GO:0005783)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum-plasma membrane contact site (GO:0140268)fat cell differentiation (GO:0045444)intermembrane phospholipid transfer (GO:0120010)lipid binding (GO:0008289)membrane (GO:0016020)membrane (GO:0016020)nuclear membrane (GO:0031965)phosphatidylinositol-4-phosphate binding (GO:0070273)phosphatidylinositol-4-phosphate binding (GO:0070273)phosphatidylserine acyl-chain remodeling (GO:0036150)phosphatidylserine acyl-chain remodeling (GO:0036150)phosphatidylserine binding (GO:0001786)phosphatidylserine binding (GO:0001786)phosphatidylserine transfer activity (GO:0140343)phosphatidylserine transfer activity (GO:0140343)phosphatidylserine-phosphatidylinositol-4-phosphate exchange activity (GO:0160270)phospholipid transport (GO:0015914)positive regulation of D-glucose import across plasma membrane (GO:0046326)positive regulation of D-glucose import across plasma membrane (GO:0046326)positive regulation of insulin receptor signaling pathway (GO:0046628)positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0051897)protein binding (GO:0005515)transporter complex (GO:1990351)triglyceride homeostasis (GO:0070328)

Expression (TPM)

TFs regulating OSBPL8 0 TFs

Transcription factors with Perturb-seq knockdown data for OSBPL8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OSBPL8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to OSBPL8

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OSBPL8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr12:75,511,106–75,512,100	1048.1 kb	Distal (>10kb) Multiome HiCAR	945
chr12:76,347,962–76,348,990	211.3 kb	Distal (>10kb) Multiome	838
chr12:76,371,854–76,372,495	187.6 kb	Distal (>10kb) Multiome	65
chr12:76,384,502–76,385,032	175.0 kb	Distal (>10kb) Multiome	65
chr12:76,558,693–76,560,264	56 bp	At TSS Multiome	1006
chr12:76,763,225–76,765,030	204.4 kb	Distal (>10kb) Multiome	982
chr12:76,780,975–76,782,664	222.2 kb	Distal (>10kb) Multiome	241

Genome Browser

Genomic view of the OSBPL8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.