This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. The encoded protein is involved in the regulation of cell adhesion and organization of the actin cytoskeleton. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Transcription factors with Perturb-seq knockdown data for OSBPL3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OSBPL3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OSBPL3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:24,725,954–24,726,590 | 253.9 kb | Distal (>10kb) Multiome | 159 | |
| chr7:24,756,703–24,758,077 | 222.8 kb | Distal (>10kb) Multiome | 609 | |
| chr7:24,910,037–24,911,071 | 69.4 kb | Distal (>10kb) Multiome | 134 | |
| chr7:24,971,370–24,972,325 | 8.4 kb | Proximal (<10kb) Multiome | 393 | |
| chr7:24,978,754–24,981,093 | 116 bp | At TSS Multiome | 889 | |
| chr7:24,981,203–24,981,948 | 1.0 kb | Proximal (<10kb) | 269 | |
| chr7:25,124,560–25,125,967 | 145.3 kb | Distal (>10kb) Multiome | 1019 | |
| chr7:25,179,707–25,180,806 | 200.1 kb | Distal (>10kb) Multiome | 607 | |
| chr7:25,243,706–25,244,747 | 264.1 kb | Distal (>10kb) Multiome | 123 |
Genomic view of the OSBPL3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.