The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ORC3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ORC3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ORC3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:87,322,367–87,323,025 | 267.6 kb | Distal (>10kb) Multiome | 892 | |
| chr6:87,407,486–87,408,928 | 181.9 kb | Distal (>10kb) Multiome | 735 | |
| chr6:87,472,409–87,473,809 | 117.1 kb | Distal (>10kb) Multiome | 913 | |
| chr6:87,483,840–87,484,329 | 105.9 kb | Distal (>10kb) Multiome | 125 | |
| chr6:87,551,523–87,552,511 | 38.3 kb | Distal (>10kb) Multiome | 64 | |
| chr6:87,589,655–87,590,489 | 73 bp | At TSS Multiome | 803 | |
| chr6:87,594,480–87,594,695 | 4.4 kb | Proximal (<10kb) | 7 | |
| chr6:87,700,848–87,703,142 | 112.3 kb | Distal (>10kb) Multiome | 974 |
Genomic view of the ORC3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.