Transcription factors with Perturb-seq knockdown data for OLMALINC. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OLMALINC upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OLMALINC, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:100,185,381–100,186,650 | 187.5 kb | Distal (>10kb) Multiome | 913 | |
| chr10:100,228,957–100,229,948 | 144.0 kb | Distal (>10kb) Multiome | 759 | |
| chr10:100,267,386–100,267,986 | 105.9 kb | Distal (>10kb) Multiome | 715 | |
| chr10:100,286,018–100,287,021 | 87.0 kb | Distal (>10kb) Multiome | 849 | |
| chr10:100,346,401–100,347,640 | 26.7 kb | Distal (>10kb) Multiome | 919 | |
| chr10:100,359,067–100,359,724 | 14.3 kb | Distal (>10kb) Multiome | 425 | |
| chr10:100,371,283–100,371,534 | 2.1 kb | Proximal (<10kb) | 656 | |
| chr10:100,372,854–100,374,386 | 88 bp | At TSS Multiome | 964 | |
| chr10:100,382,238–100,382,510 | 8.6 kb | Proximal (<10kb) | 7 | |
| chr10:100,481,576–100,482,049 | 108.1 kb | Distal (>10kb) Multiome | 298 | |
| chr10:100,482,268–100,483,078 | 109.2 kb | Distal (>10kb) Multiome | 497 | |
| chr10:100,485,778–100,486,586 | 112.5 kb | Distal (>10kb) Multiome | 161 | |
| chr10:100,518,832–100,519,948 | 145.8 kb | Distal (>10kb) Multiome | 417 | |
| chr10:100,529,444–100,530,236 | 156.3 kb | Distal (>10kb) Multiome | 619 | |
| chr10:100,535,502–100,536,234 | 162.3 kb | Distal (>10kb) Multiome | 759 | |
| chr10:100,561,994–100,562,629 | 188.6 kb | Distal (>10kb) Multiome | 491 | |
| chr10:100,654,597–100,655,452 | 281.5 kb | Distal (>10kb) Multiome | 300 | |
| chr10:100,656,014–100,657,003 | 283.1 kb | Distal (>10kb) Multiome | 310 | |
| chr10:100,670,865–100,671,507 | 297.5 kb | Distal (>10kb) Multiome | 364 |
Genomic view of the OLMALINC locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.