This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009]
Transcription factors with Perturb-seq knockdown data for OGDH. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OGDH upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OGDH, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:44,309,084–44,310,124 | 296.8 kb | Distal (>10kb) Multiome | 263 | |
| chr7:44,325,052–44,325,687 | 281.2 kb | Distal (>10kb) Multiome | 118 | |
| chr7:44,490,144–44,491,030 | 115.9 kb | Distal (>10kb) Multiome | 996 | |
| chr7:44,573,627–44,574,398 | 32.6 kb | Distal (>10kb) Multiome | 885 | |
| chr7:44,581,475–44,583,147 | 24.2 kb | Distal (>10kb) Multiome | 864 | |
| chr7:44,606,125–44,607,487 | 234 bp | At TSS Multiome | 1043 | |
| chr7:44,748,085–44,749,703 | 142.0 kb | Distal (>10kb) Multiome | 665 | |
| chr7:44,795,796–44,797,747 | 190.0 kb | Distal (>10kb) Multiome | 1094 | |
| chr7:44,847,376–44,848,800 | 241.6 kb | Distal (>10kb) Multiome | 990 | |
| chr7:44,884,668–44,886,169 | 279.0 kb | Distal (>10kb) Multiome | 956 |
Genomic view of the OGDH locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.