Involved in negative regulation of cilium assembly. Located in centriolar satellite and ciliary basal body. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ODF2L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ODF2L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ODF2L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:86,154,383–86,157,643 | 241.2 kb | Distal (>10kb) Multiome | 564 | |
| chr1:86,395,088–86,396,842 | 132 bp | At TSS Multiome | 619 | |
| chr1:86,396,948–86,397,421 | 625 bp | At TSS | 13 | |
| chr1:86,397,846–86,398,004 | 1.5 kb | Proximal (<10kb) | 4 | |
| chr1:86,398,122–86,398,373 | 1.8 kb | Proximal (<10kb) | 4 | |
| chr1:86,501,812–86,504,473 | 106.5 kb | Distal (>10kb) Multiome HiCAR | 332 |
Genomic view of the ODF2L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.