Predicted to be involved in neuron projection morphogenesis and phosphatidylinositol 3-kinase/protein kinase B signal transduction. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NYAP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NYAP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NYAP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:100,266,531–100,267,045 | 217.2 kb | Distal (>10kb) Multiome | 24 | |
| chr7:100,270,225–100,270,813 | 213.3 kb | Distal (>10kb) Multiome | 103 | |
| chr7:100,271,732–100,272,774 | 211.6 kb | Distal (>10kb) Multiome | 530 | |
| chr7:100,335,652–100,336,470 | 147.8 kb | Distal (>10kb) Multiome | 706 | |
| chr7:100,381,682–100,382,670 | 101.9 kb | Distal (>10kb) Multiome | 49 | |
| chr7:100,428,059–100,431,175 | 55.0 kb | Distal (>10kb) Multiome | 1296 | |
| chr7:100,435,379–100,436,927 | 47.4 kb | Distal (>10kb) Multiome | 931 | |
| chr7:100,450,379–100,450,973 | 33.2 kb | Distal (>10kb) Multiome | 785 | |
| chr7:100,478,582–100,479,753 | 4.5 kb | Proximal (<10kb) Multiome | 842 | |
| chr7:100,482,937–100,484,533 | 272 bp | At TSS Multiome | 677 | |
| chr7:100,538,557–100,539,759 | 55.1 kb | Distal (>10kb) Multiome | 858 | |
| chr7:100,542,221–100,542,986 | 58.8 kb | Distal (>10kb) Multiome HiCAR | 274 | |
| chr7:100,569,177–100,570,642 | 85.7 kb | Distal (>10kb) Multiome HiCAR | 855 | |
| chr7:100,585,161–100,587,241 | 102.5 kb | Distal (>10kb) Multiome | 966 | |
| chr7:100,611,685–100,612,981 | 128.3 kb | Distal (>10kb) Multiome | 767 | |
| chr7:100,626,427–100,627,057 | 142.8 kb | Distal (>10kb) Multiome | 415 | |
| chr7:100,656,111–100,656,626 | 172.5 kb | Distal (>10kb) Multiome | 653 | |
| chr7:100,673,043–100,674,892 | 189.6 kb | Distal (>10kb) Multiome | 934 | |
| chr7:100,674,996–100,676,406 | 192.0 kb | Distal (>10kb) Multiome | 439 | |
| chr7:100,691,570–100,692,163 | 207.9 kb | Distal (>10kb) Multiome | 364 | |
| chr7:100,693,475–100,694,667 | 210.4 kb | Distal (>10kb) Multiome | 607 | |
| chr7:100,705,140–100,706,426 | 222.0 kb | Distal (>10kb) Multiome | 962 |
Genomic view of the NYAP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.