Transcription factors with Perturb-seq knockdown data for NUTM2B-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NUTM2B-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NUTM2B-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:79,826,295–79,826,934 | at TSS | At TSS | 103 | |
| chr10:79,827,068–79,827,191 | 552 bp | At TSS | 36 | |
| chr10:79,904,553–79,905,313 | 78.4 kb | Distal (>10kb) Multiome | 317 | |
| chr10:79,981,449–79,982,593 | 155.5 kb | Distal (>10kb) Multiome | 420 | |
| chr10:80,076,334–80,077,082 | 250.0 kb | Distal (>10kb) Multiome | 10 | |
| chr10:80,078,334–80,079,521 | 252.5 kb | Distal (>10kb) Multiome | 806 |
Genomic view of the NUTM2B-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.