The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a membrane-spanning glycoprotein that is a major component of the nuclear pore complex. Multiple pseudogenes related to this gene are located on chromosome 3. [provided by RefSeq, Jul 2013]
Transcription factors with Perturb-seq knockdown data for NUP210. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NUP210 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NUP210, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:13,157,648–13,158,706 | 262.1 kb | Distal (>10kb) Multiome | 19 | |
| chr3:13,281,536–13,283,868 | 137.3 kb | Distal (>10kb) Multiome | 567 | |
| chr3:13,301,084–13,301,878 | 118.7 kb | Distal (>10kb) Multiome | 345 | |
| chr3:13,419,449–13,420,954 | 2 bp | At TSS Multiome | 719 | |
| chr3:13,451,423–13,452,307 | 31.6 kb | Distal (>10kb) Multiome | 750 | |
| chr3:13,479,315–13,481,211 | 60.0 kb | Distal (>10kb) Multiome | 821 | |
| chr3:13,546,672–13,547,232 | 126.7 kb | Distal (>10kb) Multiome | 324 | |
| chr3:13,548,548–13,549,592 | 128.8 kb | Distal (>10kb) Multiome | 246 | |
| chr3:13,595,157–13,596,271 | 175.5 kb | Distal (>10kb) Multiome | 155 | |
| chr3:13,648,109–13,648,809 | 228.3 kb | Distal (>10kb) Multiome | 456 | |
| chr3:13,650,360–13,650,812 | 230.4 kb | Distal (>10kb) Multiome | 720 | |
| chr3:13,655,106–13,655,809 | 235.2 kb | Distal (>10kb) Multiome | 273 |
Genomic view of the NUP210 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.