This gene encodes a hydrolase that serves as an important role in cellular purine metabolism by acting primarily on inosine 5'-monophosphate and other purine nucleotides. [provided by RefSeq, Oct 2011]
Transcription factors with Perturb-seq knockdown data for NT5C2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NT5C2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NT5C2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:102,916,941–102,919,907 | 275.1 kb | Distal (>10kb) Multiome | 984 | |
| chr10:103,192,518–103,193,861 | 33 bp | At TSS Multiome | 725 | |
| chr10:103,204,930–103,206,025 | 11.8 kb | Distal (>10kb) Multiome | 207 | |
| chr10:103,206,729–103,207,578 | 13.9 kb | Distal (>10kb) Multiome | 46 | |
| chr10:103,276,757–103,278,251 | 84.1 kb | Distal (>10kb) Multiome | 385 | |
| chr10:103,350,520–103,351,294 | 157.8 kb | Distal (>10kb) Multiome | 679 | |
| chr10:103,367,765–103,368,860 | 175.4 kb | Distal (>10kb) Multiome | 925 | |
| chr10:103,395,952–103,396,926 | 203.3 kb | Distal (>10kb) Multiome | 821 | |
| chr10:103,493,310–103,494,526 | 300.4 kb | Distal (>10kb) Multiome | 299 |
Genomic view of the NT5C2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.