Enables tRNA (cytidine-5-)-methyltransferase activity and tRNA binding activity. Involved in tRNA C5-cytosine methylation. Located in cytoplasm. Implicated in autosomal recessive intellectual developmental disorder 82. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NSUN6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NSUN6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NSUN6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:18,627,393–18,628,219 | 31.5 kb | Distal (>10kb) Multiome | 313 | |
| chr10:18,651,309–18,652,042 | 7.6 kb | Proximal (<10kb) Multiome | 806 | |
| chr10:18,658,695–18,660,169 | 103 bp | At TSS Multiome | 946 | |
| chr10:18,660,270–18,660,433 | 8.7 kb | Proximal (<10kb) | 226 | |
| chr10:18,664,882–18,665,282 | 5.6 kb | Proximal (<10kb) | 30 |
Genomic view of the NSUN6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.