This gene encodes a nucleolar protein involved in cell cycle regulation and proliferation. This gene was identified based on sequence similarity to a highly conserved Saccharomyces cerevisiae gene encoding a pre-ribosomal protein, which is involved in large ribosomal subunit biogenesis. The encoded protein is found at elevated levels in diabetic nephropathy. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified. [provided by RefSeq, Nov 2012]
Transcription factors with Perturb-seq knockdown data for NSA2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NSA2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NSA2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:74,507,243–74,508,516 | 259.3 kb | Distal (>10kb) Multiome | 61 | |
| chr5:74,515,759–74,516,668 | 250.9 kb | Distal (>10kb) Multiome | 152 | |
| chr5:74,536,561–74,538,457 | 229.4 kb | Distal (>10kb) Multiome | 426 | |
| chr5:74,543,139–74,544,218 | 223.6 kb | Distal (>10kb) Multiome | 418 | |
| chr5:74,555,513–74,556,350 | 211.1 kb | Distal (>10kb) Multiome | 100 | |
| chr5:74,625,689–74,626,268 | 141.3 kb | Distal (>10kb) Multiome | 148 | |
| chr5:74,631,192–74,632,778 | 135.8 kb | Distal (>10kb) Multiome | 598 | |
| chr5:74,639,680–74,641,657 | 126.4 kb | Distal (>10kb) Multiome | 999 | |
| chr5:74,684,927–74,685,413 | 82.0 kb | Distal (>10kb) Multiome | 765 | |
| chr5:74,765,016–74,765,573 | 1.7 kb | Proximal (<10kb) | 46 | |
| chr5:74,766,697–74,767,753 | 67 bp | At TSS Multiome | 976 | |
| chr5:74,865,358–74,867,179 | 99.0 kb | Distal (>10kb) Multiome | 747 | |
| chr5:74,882,799–74,883,395 | 115.7 kb | Distal (>10kb) Multiome | 109 | |
| chr5:74,903,262–74,903,711 | 136.3 kb | Distal (>10kb) Multiome HiCAR | 301 | |
| chr5:75,052,462–75,054,650 | 286.5 kb | Distal (>10kb) Multiome | 602 |
Genomic view of the NSA2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.