Predicted to be involved in axon regeneration; regulation of neuron differentiation; and regulation of transforming growth factor beta receptor signaling pathway. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NREP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NREP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NREP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:111,511,588–111,513,437 | 245.1 kb | Distal (>10kb) Multiome | 1035 | |
| chr5:111,548,011–111,549,940 | 208.9 kb | Distal (>10kb) Multiome | 416 | |
| chr5:111,755,622–111,756,261 | 902 bp | At TSS | 115 | |
| chr5:111,756,861–111,758,380 | 9 bp | At TSS Multiome | 939 | |
| chr5:111,758,795–111,758,946 | 1.6 kb | Proximal (<10kb) | 11 | |
| chr5:111,934,060–111,935,563 | 177.2 kb | Distal (>10kb) Multiome | 205 |
Genomic view of the NREP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.