The protein encoded by this gene is a DNA-binding zinc finger transcription factor and is a member of the fushi tarazu factor-1 subfamily of orphan nuclear receptors. The encoded protein is involved in the expression of genes for hepatitis B virus and cholesterol biosynthesis, and may be an important regulator of embryonic development. [provided by RefSeq, Jun 2016]
Transcription factors with Perturb-seq knockdown data for NR5A2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NR5A2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NR5A2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:199,865,801–199,866,542 | 176.7 kb | Distal (>10kb) Multiome | 82 | |
| chr1:200,028,688–200,030,182 | 13.5 kb | Distal (>10kb) Multiome | 492 | |
| chr1:200,033,466–200,035,193 | 8.3 kb | Proximal (<10kb) Multiome | 174 | |
| chr1:200,035,389–200,036,859 | 6.0 kb | Proximal (<10kb) | 141 | |
| chr1:200,038,105–200,040,422 | 3.8 kb | Proximal (<10kb) Multiome | 520 | |
| chr1:200,040,516–200,041,200 | 1.6 kb | Proximal (<10kb) | 433 | |
| chr1:200,041,315–200,042,953 | at TSS | At TSS | 241 | |
| chr1:200,043,203–200,043,419 | 379 bp | At TSS | 64 | |
| chr1:200,048,013–200,048,823 | 5.6 kb | Proximal (<10kb) Multiome | 215 | |
| chr1:200,129,357–200,130,017 | 86.9 kb | Distal (>10kb) Multiome | 129 | |
| chr1:200,225,879–200,226,951 | 183.6 kb | Distal (>10kb) Multiome | 304 | |
| chr1:200,275,106–200,277,040 | 232.7 kb | Distal (>10kb) Multiome | 305 |
Genomic view of the NR5A2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.