This gene encodes a type I transmembrane protein belonging to the Ig superfamily. The protein is believed to be involved in cell-cell interactions or cell-substrate interactions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2009]
Transcription factors with Perturb-seq knockdown data for NPTN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NPTN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NPTN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:73,367,615–73,369,384 | 264.6 kb | Distal (>10kb) Multiome | 294 | |
| chr15:73,632,366–73,634,024 | 50 bp | At TSS Multiome | 802 | |
| chr15:73,636,471–73,636,966 | 3.2 kb | Proximal (<10kb) Multiome | 427 | |
| chr15:73,683,662–73,685,097 | 50.9 kb | Distal (>10kb) Multiome | 641 | |
| chr15:73,733,109–73,733,828 | 100.1 kb | Distal (>10kb) Multiome | 33 | |
| chr15:73,752,465–73,753,181 | 119.5 kb | Distal (>10kb) Multiome | 192 | |
| chr15:73,926,301–73,928,142 | 294.4 kb | Distal (>10kb) Multiome | 557 |
Genomic view of the NPTN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.