NPLOC4
NPL4 homolog, ubiquitin recognition factor | FLJ20657, KIAA1499, NPL4

Predicted to enable ubiquitin binding activity and ubiquitin protein ligase binding activity. Predicted to contribute to K48-linked polyubiquitin modification-dependent protein binding activity and K63-linked polyubiquitin modification-dependent protein binding activity. Involved in negative regulation of RIG-I signaling pathway; negative regulation of type I interferon production; and proteolysis involved in protein catabolic process. Located in nucleus. Part of UFD1-NPL4 complex and VCP-NPL4-UFD1 AAA ATPase complex. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-2
Biological processes 40 terms
ATPase binding (GO:0051117)ERAD pathway (GO:0036503)ERAD pathway (GO:0036503)Golgi organization (GO:0007030)Golgi organization (GO:0007030)K48-linked polyubiquitin modification-dependent protein binding (GO:0036435)K63-linked polyubiquitin modification-dependent protein binding (GO:0070530)UFD1-NPL4 complex (GO:0036501)UFD1-NPL4 complex (GO:0036501)VCP-NPL4-UFD1 AAA ATPase complex (GO:0034098)VCP-NPL4-UFD1 AAA ATPase complex (GO:0034098)VCP-NPL4-UFD1 AAA ATPase complex (GO:0034098)cytosol (GO:0005829)cytosol (GO:0005829)endoplasmic reticulum (GO:0005783)endoplasmic reticulum (GO:0005783)negative regulation of RIG-I signaling pathway (GO:0039536)negative regulation of type I interferon production (GO:0032480)nuclear outer membrane-endoplasmic reticulum membrane network (GO:0042175)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)protein binding (GO:0005515)protein-containing complex binding (GO:0044877)rescue of stalled cytosolic ribosome (GO:0072344)retrograde protein transport, ER to cytosol (GO:0030970)retrograde protein transport, ER to cytosol (GO:0030970)ribosome-associated ubiquitin-dependent protein catabolic process (GO:1990116)ubiquitin binding (GO:0043130)ubiquitin binding (GO:0043130)ubiquitin protein ligase binding (GO:0031625)ubiquitin protein ligase binding (GO:0031625)ubiquitin-dependent protein catabolic process (GO:0006511)ubiquitin-dependent protein catabolic process (GO:0006511)ubiquitin-dependent protein catabolic process (GO:0006511)ubiquitin-dependent protein catabolic process (GO:0006511)
Expression (TPM)
NPLOC4 — as a Regulated Gene

TFs regulating NPLOC4 0 TFs

Transcription factors with Perturb-seq knockdown data for NPLOC4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NPLOC4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to NPLOC4

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NPLOC4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr17:81,393,141–81,395,575 254.4 kb Distal (>10kb) Multiome 1168
chr17:81,396,480–81,397,832 251.1 kb Distal (>10kb) Multiome 646
chr17:81,481,258–81,481,865 166.9 kb Distal (>10kb) Multiome 348
chr17:81,483,927–81,484,829 164.0 kb Distal (>10kb) Multiome 828
chr17:81,487,690–81,488,371 160.5 kb Distal (>10kb) Multiome 721
chr17:81,511,887–81,515,656 135.5 kb Distal (>10kb) Multiome 1116
chr17:81,518,632–81,519,878 128.9 kb Distal (>10kb) Multiome 617
chr17:81,537,462–81,537,907 110.8 kb Distal (>10kb) Multiome 282
chr17:81,551,821–81,553,314 95.3 kb Distal (>10kb) Multiome 845
chr17:81,636,404–81,637,301 11.4 kb Distal (>10kb) Multiome 946
chr17:81,648,048–81,648,550 213 bp At TSS Multiome 88
chr17:81,652,970–81,653,572 4.7 kb Proximal (<10kb) Multiome 188
chr17:81,666,251–81,667,166 18.2 kb Distal (>10kb) Multiome 901
chr17:81,683,344–81,684,556 35.4 kb Distal (>10kb) Multiome 926
chr17:81,702,879–81,703,868 54.9 kb Distal (>10kb) Multiome 981
chr17:81,711,721–81,712,812 63.8 kb Distal (>10kb) Multiome 1056
chr17:81,832,473–81,833,976 184.8 kb Distal (>10kb) Multiome 1015
chr17:81,859,762–81,861,595 212.4 kb Distal (>10kb) Multiome 1134
chr17:81,868,421–81,868,978 220.1 kb Distal (>10kb) Multiome 577
chr17:81,869,000–81,872,289 222.8 kb Distal (>10kb) Multiome 1136
chr17:81,891,143–81,892,257 243.3 kb Distal (>10kb) Multiome 969
chr17:81,910,443–81,911,980 263.1 kb Distal (>10kb) Multiome 806
chr17:81,917,586–81,918,522 269.7 kb Distal (>10kb) Multiome 619
chr17:81,923,285–81,923,863 275.1 kb Distal (>10kb) Multiome 399
chr17:81,926,141–81,929,133 279.4 kb Distal (>10kb) Multiome 1034
chr17:81,936,855–81,937,682 288.9 kb Distal (>10kb) Multiome 854

Genome Browser

Genomic view of the NPLOC4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr17:81,383,141 – 81,947,682
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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