This gene encodes the puromycin-sensitive aminopeptidase, a zinc metallopeptidase which hydrolyzes amino acids from the N-terminus of its substrate. The protein has been localized to both the cytoplasm and to cellular membranes. This enzyme degrades enkaphalins in the brain, and studies in mouse suggest that it is involved in proteolytic events regulating the cell cycle. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for NPEPPS. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NPEPPS upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NPEPPS, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:47,253,593–47,254,400 | 277.3 kb | Distal (>10kb) Multiome | 571 | |
| chr17:47,275,398–47,275,943 | 255.6 kb | Distal (>10kb) Multiome | 340 | |
| chr17:47,310,107–47,310,844 | 220.8 kb | Distal (>10kb) Multiome | 92 | |
| chr17:47,323,422–47,324,660 | 207.3 kb | Distal (>10kb) Multiome | 1009 | |
| chr17:47,423,404–47,423,999 | 107.5 kb | Distal (>10kb) Multiome | 129 | |
| chr17:47,530,872–47,531,289 | at TSS | At TSS | 162 | |
| chr17:47,531,659–47,532,268 | 986 bp | At TSS Multiome | 159 | |
| chr17:47,648,863–47,650,987 | 118.4 kb | Distal (>10kb) Multiome | 1152 | |
| chr17:47,693,705–47,695,210 | 163.3 kb | Distal (>10kb) Multiome | 619 | |
| chr17:47,733,002–47,733,810 | 202.0 kb | Distal (>10kb) Multiome | 366 | |
| chr17:47,789,633–47,790,336 | 258.8 kb | Distal (>10kb) Multiome | 395 | |
| chr17:47,831,256–47,831,955 | 300.4 kb | Distal (>10kb) Multiome | 856 |
Genomic view of the NPEPPS locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.