The protein encoded by this gene is highly similar to Nocturnin, a gene identified as a circadian clock regulated gene in Xenopus laevis. This protein and Nocturnin protein share similarity with the C-terminal domain of a yeast transcription factor, carbon catabolite repression 4 (CCR4). The mRNA abundance of a similar gene in mouse has been shown to exhibit circadian rhythmicity, which suggests a role for this protein in clock function or as a circadian clock effector. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for NOCT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NOCT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NOCT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:138,816,572–138,817,315 | 198.8 kb | Distal (>10kb) Multiome | 211 | |
| chr4:138,910,598–138,911,729 | 104.7 kb | Distal (>10kb) Multiome | 566 | |
| chr4:138,936,704–138,937,523 | 78.7 kb | Distal (>10kb) Multiome | 74 | |
| chr4:138,974,508–138,975,556 | 41.0 kb | Distal (>10kb) Multiome HiCAR | 150 | |
| chr4:139,014,635–139,016,468 | 91 bp | At TSS Multiome | 975 | |
| chr4:139,017,540–139,017,795 | 1.8 kb | Proximal (<10kb) | 45 | |
| chr4:139,020,400–139,021,056 | 4.9 kb | Proximal (<10kb) Multiome HiCAR | 167 | |
| chr4:139,082,831–139,084,775 | 67.3 kb | Distal (>10kb) Multiome | 1056 | |
| chr4:139,159,062–139,160,313 | 144.0 kb | Distal (>10kb) Multiome | 133 | |
| chr4:139,176,009–139,179,224 | 162.3 kb | Distal (>10kb) Multiome | 1018 | |
| chr4:139,279,361–139,280,628 | 264.4 kb | Distal (>10kb) Multiome | 287 | |
| chr4:139,295,267–139,296,002 | 280.0 kb | Distal (>10kb) Multiome | 947 | |
| chr4:139,300,735–139,302,627 | 285.6 kb | Distal (>10kb) Multiome | 912 |
Genomic view of the NOCT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.