Histone modification by histone acetyltransferases (HAT) and histone deacetylases (HDAC) can control major aspects of transcriptional regulation. NOC2L represents a novel HDAC-independent inhibitor of histone acetyltransferase (INHAT) (Hublitz et al., 2005 [PubMed 16322561]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for NOC2L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NOC2L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NOC2L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:904,256–904,920 | 54.5 kb | Distal (>10kb) Multiome | 590 | |
| chr1:923,612–925,339 | 35.4 kb | Distal (>10kb) Multiome | 500 | |
| chr1:939,835–943,080 | 17.3 kb | Distal (>10kb) Multiome | 864 | |
| chr1:959,035–960,017 | 69 bp | At TSS Multiome | 622 | |
| chr1:960,291–961,429 | 1.5 kb | Proximal (<10kb) Multiome | 552 | |
| chr1:966,272–967,306 | 7.0 kb | Proximal (<10kb) | 594 | |
| chr1:975,960–976,521 | 17.0 kb | Distal (>10kb) Multiome | 476 | |
| chr1:998,350–1,000,999 | 41.1 kb | Distal (>10kb) Multiome | 1047 | |
| chr1:1,001,349–1,002,099 | 42.7 kb | Distal (>10kb) Multiome | 646 | |
| chr1:1,005,015–1,005,702 | 46.0 kb | Distal (>10kb) Multiome | 532 | |
| chr1:1,019,142–1,021,414 | 60.4 kb | Distal (>10kb) Multiome | 707 | |
| chr1:1,032,438–1,034,753 | 74.0 kb | Distal (>10kb) Multiome | 475 | |
| chr1:1,040,071–1,041,597 | 81.7 kb | Distal (>10kb) Multiome | 410 | |
| chr1:1,058,856–1,060,114 | 100.3 kb | Distal (>10kb) Multiome | 609 | |
| chr1:1,068,556–1,069,991 | 110.0 kb | Distal (>10kb) Multiome | 577 | |
| chr1:1,079,478–1,080,558 | 120.8 kb | Distal (>10kb) Multiome | 746 | |
| chr1:1,115,769–1,117,022 | 157.0 kb | Distal (>10kb) Multiome | 743 | |
| chr1:1,157,424–1,158,362 | 198.3 kb | Distal (>10kb) Multiome | 575 | |
| chr1:1,200,907–1,201,739 | 242.2 kb | Distal (>10kb) Multiome | 430 | |
| chr1:1,231,448–1,233,390 | 272.9 kb | Distal (>10kb) Multiome | 884 |
Genomic view of the NOC2L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.