Predicted to enable GTPase activating protein binding activity. Predicted to be involved in Ral protein signal transduction. Predicted to act upstream of or within lung alveolus development; regulation of tumor necrosis factor-mediated signaling pathway; and surfactant homeostasis. Located in cytosol and endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NKIRAS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NKIRAS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NKIRAS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:23,701,633–23,702,476 | 215.0 kb | Distal (>10kb) Multiome | 210 | |
| chr3:23,805,437–23,807,461 | 111.1 kb | Distal (>10kb) Multiome | 636 | |
| chr3:23,809,943–23,811,474 | 106.4 kb | Distal (>10kb) Multiome | 685 | |
| chr3:23,916,365–23,917,803 | 75 bp | At TSS Multiome | 1082 | |
| chr3:23,921,007–23,921,435 | 4.1 kb | Proximal (<10kb) | 221 | |
| chr3:23,921,593–23,922,234 | 4.6 kb | Proximal (<10kb) | 67 | |
| chr3:23,922,421–23,923,129 | 5.5 kb | Proximal (<10kb) | 17 | |
| chr3:23,938,713–23,939,267 | 22.0 kb | Distal (>10kb) Multiome | 172 | |
| chr3:23,944,552–23,946,922 | 28.1 kb | Distal (>10kb) Multiome | 1112 | |
| chr3:23,953,236–23,954,388 | 36.8 kb | Distal (>10kb) Multiome | 152 |
Genomic view of the NKIRAS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.