Predicted to be involved in RNA processing. Predicted to be located in nucleolus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NIFK-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NIFK-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NIFK-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:121,529,786–121,532,189 | 118.8 kb | Distal (>10kb) Multiome | 1343 | |
| chr2:121,648,584–121,650,422 | 7 bp | At TSS Multiome | 1043 | |
| chr2:121,680,120–121,680,609 | 30.7 kb | Distal (>10kb) Multiome | 87 | |
| chr2:121,736,354–121,737,978 | 87.4 kb | Distal (>10kb) Multiome | 878 | |
| chr2:121,745,785–121,746,842 | 96.7 kb | Distal (>10kb) Multiome | 195 | |
| chr2:121,754,998–121,756,033 | 106.0 kb | Distal (>10kb) Multiome | 944 |
Genomic view of the NIFK-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.