This gene encodes a protein that interacts with the forkhead-associated domain of the Ki-67 antigen. The encoded protein may bind RNA and may play a role in mitosis and cell cycle progression. Multiple pseudogenes exist on chromosomes 5, 10, 12, 15, and 19.[provided by RefSeq, Jan 2009]
Transcription factors with Perturb-seq knockdown data for NIFK. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NIFK upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NIFK, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:121,529,786–121,532,189 | 206.1 kb | Distal (>10kb) Multiome | 1343 | |
| chr2:121,648,584–121,650,422 | 87.3 kb | Distal (>10kb) Multiome | 1043 | |
| chr2:121,680,120–121,680,609 | 56.6 kb | Distal (>10kb) Multiome | 87 | |
| chr2:121,736,354–121,737,978 | 148 bp | At TSS Multiome | 878 | |
| chr2:121,745,785–121,746,842 | 9.4 kb | Proximal (<10kb) Multiome | 195 | |
| chr2:121,754,998–121,756,033 | 18.7 kb | Distal (>10kb) Multiome | 944 |
Genomic view of the NIFK locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.