This gene encodes a member of the family with sequence similarity 129 protein family. This gene is highly expressed in several cancer cells and may serve as a prognostic marker for certain cancers. The encoded protein may play a role in regulating p53-mediated apoptosis. [provided by RefSeq, Sep 2016]
Transcription factors with Perturb-seq knockdown data for NIBAN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NIBAN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NIBAN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:184,695,922–184,696,742 | 278.1 kb | Distal (>10kb) Multiome | 40 | |
| chr1:184,754,064–184,755,736 | 219.5 kb | Distal (>10kb) Multiome | 971 | |
| chr1:184,905,067–184,906,277 | 68.8 kb | Distal (>10kb) Multiome | 314 | |
| chr1:184,973,585–184,974,868 | 313 bp | At TSS Multiome | 731 | |
| chr1:184,982,167–184,982,432 | 7.7 kb | Proximal (<10kb) | 322 | |
| chr1:185,044,828–185,046,417 | 70.9 kb | Distal (>10kb) Multiome | 816 | |
| chr1:185,156,218–185,158,419 | 182.7 kb | Distal (>10kb) Multiome | 949 |
Genomic view of the NIBAN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.