NGFR

nerve growth factor receptor | CD271, TNFRSF16, p75NTR

Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. [provided by RefSeq, Jul 2008]

Developmental clusters: GC4

Biological processes 62 terms

Rho protein signal transduction (GO:0007266)Rho protein signal transduction (GO:0007266)amyloid-beta binding (GO:0001540)calmodulin binding (GO:0005516)cell surface (GO:0009986)cell surface (GO:0009986)cell surface (GO:0009986)cell-cell junction (GO:0005911)cellular response to amyloid-beta (GO:1904646)circadian regulation of gene expression (GO:0032922)circadian regulation of gene expression (GO:0032922)circadian rhythm (GO:0007623)coreceptor activity (GO:0015026)coreceptor activity (GO:0015026)cytoplasm (GO:0005737)cytosol (GO:0005829)death receptor activity (GO:0005035)death receptor activity (GO:0005035)death receptor activity (GO:0005035)dendritic spine (GO:0043197)dorsal aorta development (GO:0035907)endosome (GO:0005768)extracellular region (GO:0005576)extrinsic apoptotic signaling pathway (GO:0097191)glucose homeostasis (GO:0042593)glucose homeostasis (GO:0042593)growth cone (GO:0030426)intracellular glucose homeostasis (GO:0001678)intracellular glucose homeostasis (GO:0001678)intracellular protein transport (GO:0006886)intracellular protein transport (GO:0006886)membrane (GO:0016020)negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis (GO:1903588)negative regulation of cell migration (GO:0030336)nerve growth factor binding (GO:0048406)nerve growth factor binding (GO:0048406)nerve growth factor binding (GO:0048406)neuromuscular junction (GO:0031594)neuron apoptotic process (GO:0051402)neurotrophin binding (GO:0043121)nucleoplasm (GO:0005654)organelle (GO:0043226)perikaryon (GO:0043204)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of apoptotic process (GO:0043065)positive regulation of endothelial cell apoptotic process (GO:2000353)positive regulation of miRNA transcription (GO:1902895)positive regulation of protein localization to nucleus (GO:1900182)postsynaptic density (GO:0014069)presynapse (GO:0098793)presynaptic modulation of chemical synaptic transmission (GO:0099171)protein binding (GO:0005515)regulation of cell population proliferation (GO:0042127)signal transduction (GO:0007165)signaling receptor activity (GO:0038023)small GTPase binding (GO:0031267)small GTPase binding (GO:0031267)transmembrane signaling receptor activity (GO:0004888)ubiquitin protein ligase binding (GO:0031625)

Expression (TPM)

TFs regulating NGFR 0 TFs

Transcription factors with Perturb-seq knockdown data for NGFR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NGFR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to NGFR

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NGFR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr17:49,223,535–49,224,633	271.5 kb	Distal (>10kb) Multiome	281
chr17:49,230,380–49,231,209	264.4 kb	Distal (>10kb) Multiome	496
chr17:49,361,317–49,363,214	132.9 kb	Distal (>10kb) Multiome	873
chr17:49,371,314–49,372,084	123.7 kb	Distal (>10kb) Multiome	235
chr17:49,414,619–49,415,442	80.3 kb	Distal (>10kb) Multiome	829
chr17:49,486,189–49,486,812	8.8 kb	Proximal (<10kb) Multiome	147
chr17:49,494,780–49,495,773	116 bp	At TSS Multiome	386
chr17:49,496,269–49,496,902	977 bp	At TSS	440
chr17:49,497,462–49,497,966	2.6 kb	Proximal (<10kb) Multiome	280
chr17:49,508,179–49,508,962	13.3 kb	Distal (>10kb) Multiome	380
chr17:49,556,195–49,556,772	61.1 kb	Distal (>10kb) Multiome	636
chr17:49,567,907–49,568,549	72.9 kb	Distal (>10kb) Multiome	623
chr17:49,569,780–49,570,501	74.9 kb	Distal (>10kb) Multiome	893
chr17:49,575,427–49,577,397	80.5 kb	Distal (>10kb) Multiome	657
chr17:49,677,242–49,678,492	182.8 kb	Distal (>10kb) Multiome	1110
chr17:49,707,638–49,708,519	212.9 kb	Distal (>10kb) Multiome	927
chr17:49,763,285–49,764,743	269.0 kb	Distal (>10kb) Multiome	768
chr17:49,788,330–49,789,442	293.9 kb	Distal (>10kb) Multiome	1068

Genome Browser

Genomic view of the NGFR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.