This gene encodes a filamentous actin-binding protein that may function in cell adhesion and migration. Mutations in this gene have been associated with dilated cardiomyopathy, also known as CMD1CC. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010]
Transcription factors with Perturb-seq knockdown data for NEXN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NEXN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NEXN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:76,074,255–76,075,430 | 1813.8 kb | Distal (>10kb) Multiome HiCAR | 452 | |
| chr1:77,681,742–77,684,058 | 205.1 kb | Distal (>10kb) Multiome | 1050 | |
| chr1:77,686,763–77,688,131 | 200.8 kb | Distal (>10kb) Multiome | 208 | |
| chr1:77,758,895–77,760,199 | 128.7 kb | Distal (>10kb) Multiome | 856 | |
| chr1:77,779,465–77,780,294 | 108.8 kb | Distal (>10kb) Multiome | 779 | |
| chr1:77,888,069–77,889,521 | 202 bp | At TSS Multiome | 648 | |
| chr1:77,906,727–77,907,344 | 18.6 kb | Distal (>10kb) Multiome | 128 | |
| chr1:77,978,065–77,980,001 | 90.7 kb | Distal (>10kb) Multiome | 993 | |
| chr1:78,045,313–78,046,896 | 157.7 kb | Distal (>10kb) Multiome | 583 | |
| chr1:78,200,021–78,201,015 | 311.9 kb | Distal (>10kb) Multiome | 129 | |
| chr1:78,214,003–78,214,778 | 326.0 kb | Distal (>10kb) Multiome | 12 |
Genomic view of the NEXN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.