NIMA-related kinases share high amino acid sequence identity with the gene product of the Aspergillus nidulans 'never in mitosis A' gene, which controls initiation of mitosis.[supplied by OMIM, Jul 2002]
Transcription factors with Perturb-seq knockdown data for NEK7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NEK7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NEK7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:197,902,087–197,903,468 | 254.2 kb | Distal (>10kb) Multiome | 980 | |
| chr1:197,910,581–197,914,043 | 245.5 kb | Distal (>10kb) Multiome | 366 | |
| chr1:197,915,230–197,918,701 | 241.0 kb | Distal (>10kb) Multiome | 575 | |
| chr1:198,149,657–198,149,834 | 7.2 kb | Proximal (<10kb) | 11 | |
| chr1:198,156,013–198,158,204 | 14 bp | At TSS Multiome | 964 | |
| chr1:198,158,321–198,159,515 | 2.2 kb | Proximal (<10kb) Multiome | 667 | |
| chr1:198,314,393–198,315,721 | 158.0 kb | Distal (>10kb) Multiome | 219 | |
| chr1:198,701,348–198,702,544 | 544.9 kb | Distal (>10kb) Multiome HiCAR | 113 |
Genomic view of the NEK7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.