The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Alternative splicing occurs at this locus and three transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jan 2011]
Transcription factors with Perturb-seq knockdown data for NDUFB6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NDUFB6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NDUFB6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:32,344,322–32,345,899 | 228.4 kb | Distal (>10kb) Multiome | 320 | |
| chr9:32,383,941–32,385,359 | 188.5 kb | Distal (>10kb) Multiome HiCAR | 770 | |
| chr9:32,524,630–32,526,749 | 48.1 kb | Distal (>10kb) Multiome | 802 | |
| chr9:32,550,146–32,552,913 | 22.2 kb | Distal (>10kb) Multiome | 1007 | |
| chr9:32,572,342–32,573,474 | 4 bp | At TSS Multiome | 817 | |
| chr9:32,579,822–32,579,987 | 6.7 kb | Proximal (<10kb) | 101 | |
| chr9:32,580,735–32,582,072 | 7.6 kb | Proximal (<10kb) | 216 | |
| chr9:32,782,490–32,784,047 | 210.3 kb | Distal (>10kb) Multiome | 305 | |
| chr9:32,950,445–32,951,255 | 377.7 kb | Distal (>10kb) Multiome HiCAR | 12 |
Genomic view of the NDUFB6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.