This gene encodes a non-catalytic subunit of the multisubunit NADH:ubiquinone oxidoreductase, the first enzyme complex in the mitochondrial electron transport chain (complex I). Mammalian complex I is composed of 45 different subunits and transfers electrons from NADH to ubiquinone. [provided by RefSeq, Dec 2009]
Transcription factors with Perturb-seq knockdown data for NDUFB4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NDUFB4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NDUFB4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:120,348,500–120,350,077 | 247.1 kb | Distal (>10kb) Multiome | 1003 | |
| chr3:120,416,932–120,417,959 | 178.9 kb | Distal (>10kb) Multiome | 482 | |
| chr3:120,450,045–120,452,154 | 145.3 kb | Distal (>10kb) Multiome | 496 | |
| chr3:120,558,699–120,560,290 | 37.2 kb | Distal (>10kb) Multiome | 654 | |
| chr3:120,595,704–120,596,910 | 12 bp | At TSS Multiome | 683 | |
| chr3:120,604,594–120,605,753 | 8.9 kb | Proximal (<10kb) Multiome | 62 | |
| chr3:120,622,775–120,623,611 | 26.8 kb | Distal (>10kb) Multiome | 221 | |
| chr3:120,677,217–120,678,016 | 81.1 kb | Distal (>10kb) Multiome | 75 | |
| chr3:120,719,201–120,720,128 | 123.3 kb | Distal (>10kb) Multiome | 147 | |
| chr3:120,741,971–120,743,234 | 146.2 kb | Distal (>10kb) Multiome | 788 |
Genomic view of the NDUFB4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.