The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. This protein has NADH dehydrogenase activity and oxidoreductase activity. It plays a important role in transfering electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Hydropathy analysis revealed that this subunit and 4 other subunits have an overall hydrophilic pattern, even though they are found within the hydrophobic protein (HP) fraction of complex I. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for NDUFB2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NDUFB2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NDUFB2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:140,397,976–140,398,715 | 298.2 kb | Distal (>10kb) Multiome | 696 | |
| chr7:140,403,831–140,404,498 | 292.6 kb | Distal (>10kb) Multiome | 333 | |
| chr7:140,455,562–140,456,050 | 240.8 kb | Distal (>10kb) Multiome | 50 | |
| chr7:140,478,495–140,480,078 | 217.2 kb | Distal (>10kb) Multiome | 869 | |
| chr7:140,481,148–140,482,022 | 215.1 kb | Distal (>10kb) Multiome | 15 | |
| chr7:140,488,120–140,488,789 | 208.2 kb | Distal (>10kb) Multiome | 230 | |
| chr7:140,517,960–140,518,418 | 178.5 kb | Distal (>10kb) Multiome | 472 | |
| chr7:140,541,306–140,541,982 | 154.9 kb | Distal (>10kb) Multiome | 422 | |
| chr7:140,639,882–140,641,732 | 55.9 kb | Distal (>10kb) Multiome | 486 | |
| chr7:140,672,673–140,674,052 | 23.7 kb | Distal (>10kb) Multiome | 648 | |
| chr7:140,696,318–140,697,705 | 146 bp | At TSS Multiome | 1002 | |
| chr7:140,924,039–140,925,334 | 228.2 kb | Distal (>10kb) Multiome | 930 | |
| chr7:141,014,405–141,015,593 | 318.4 kb | Distal (>10kb) Multiome HiCAR | 1023 |
Genomic view of the NDUFB2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.