The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is located at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to ubiquinone. Mutations in the human gene are associated with linear skin defects with multiple congenital anomalies 3 and mitochondrial complex I deficiency. [provided by RefSeq, Dec 2016]
Transcription factors with Perturb-seq knockdown data for NDUFB11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NDUFB11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NDUFB11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:46,903,672–46,904,257 | 240.8 kb | Distal (>10kb) Multiome | 417 | |
| chrX:46,912,095–46,913,434 | 232.2 kb | Distal (>10kb) Multiome | 558 | |
| chrX:47,129,095–47,129,667 | 15.4 kb | Distal (>10kb) Multiome | 538 | |
| chrX:47,144,621–47,145,590 | 377 bp | At TSS Multiome | 649 | |
| chrX:47,190,608–47,191,059 | 46.0 kb | Distal (>10kb) Multiome | 536 | |
| chrX:47,191,642–47,192,226 | 47.3 kb | Distal (>10kb) Multiome | 138 | |
| chrX:47,193,067–47,193,943 | 49.0 kb | Distal (>10kb) Multiome | 651 | |
| chrX:47,217,449–47,219,337 | 73.3 kb | Distal (>10kb) Multiome | 736 | |
| chrX:47,232,860–47,233,865 | 88.9 kb | Distal (>10kb) Multiome | 684 | |
| chrX:47,321,409–47,321,883 | 176.9 kb | Distal (>10kb) Multiome | 127 | |
| chrX:47,361,756–47,362,456 | 217.4 kb | Distal (>10kb) Multiome | 297 | |
| chrX:47,381,691–47,382,470 | 237.5 kb | Distal (>10kb) Multiome | 17 |
Genomic view of the NDUFB11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.