NDEL1
nudE neurodevelopment protein 1 like 1 | MITAP1, NDE1L1, NDE2, NUDEL

Enables identical protein binding activity. Involved in chromosome segregation; positive regulation of GTPase activity; and regulation of intracellular protein transport. Located in kinetochore. Biomarker of schizophrenia. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-10
Biological processes 41 terms
alpha-tubulin binding (GO:0043014)axon (GO:0030424)axon hillock (GO:0043203)beta-tubulin binding (GO:0048487)cell leading edge (GO:0031252)cell migration (GO:0016477)centrosome (GO:0005813)centrosome (GO:0005813)centrosome localization (GO:0051642)cerebral cortex radially oriented cell migration (GO:0021799)chromosome localization (GO:0050000)chromosome segregation (GO:0007059)chromosome segregation (GO:0007059)cytoskeleton (GO:0005856)cytosol (GO:0005829)establishment of mitotic spindle orientation (GO:0000132)identical protein binding (GO:0042802)identical protein binding (GO:0042802)insulin receptor signaling pathway (GO:0008286)kinesin complex (GO:0005871)kinetochore (GO:0000776)kinetochore (GO:0000776)lysosome localization (GO:0032418)lysosome localization (GO:0032418)microtubule associated complex (GO:0005875)microtubule binding (GO:0008017)microtubule binding (GO:0008017)microtubule nucleation (GO:0007020)microtubule organizing center (GO:0005815)mitotic centrosome separation (GO:0007100)neurofilament cytoskeleton (GO:0060053)positive regulation of GTPase activity (GO:0043547)positive regulation of ruffle assembly (GO:1900029)positive regulation of ruffle assembly (GO:1900029)protein binding (GO:0005515)regulation of intracellular protein transport (GO:0033157)regulation of neuron projection development (GO:0010975)regulation of neuron projection development (GO:0010975)spindle (GO:0005819)synaptic vesicle (GO:0008021)vesicle transport along microtubule (GO:0047496)
Expression (TPM)
NDEL1 — as a Regulated Gene

TFs regulating NDEL1 0 TFs

Transcription factors with Perturb-seq knockdown data for NDEL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NDEL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to NDEL1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NDEL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr17:8,138,425–8,139,804 296.9 kb Distal (>10kb) Multiome 981
chr17:8,151,026–8,151,640 284.6 kb Distal (>10kb) Multiome 435
chr17:8,151,914–8,152,786 283.4 kb Distal (>10kb) Multiome 633
chr17:8,153,878–8,154,864 281.5 kb Distal (>10kb) Multiome 644
chr17:8,155,928–8,157,418 279.3 kb Distal (>10kb) Multiome 789
chr17:8,162,377–8,163,907 272.8 kb Distal (>10kb) Multiome 637
chr17:8,172,460–8,174,346 262.4 kb Distal (>10kb) Multiome 1196
chr17:8,175,900–8,176,943 259.5 kb Distal (>10kb) Multiome 601
chr17:8,185,937–8,188,084 248.1 kb Distal (>10kb) Multiome 1065
chr17:8,189,376–8,190,688 245.6 kb Distal (>10kb) Multiome 748
chr17:8,192,025–8,192,719 243.5 kb Distal (>10kb) Multiome 452
chr17:8,210,139–8,210,786 225.3 kb Distal (>10kb) Multiome 778
chr17:8,220,662–8,224,088 212.9 kb Distal (>10kb) Multiome 1171
chr17:8,226,529–8,227,280 209.1 kb Distal (>10kb) Multiome 565
chr17:8,247,519–8,249,589 186.5 kb Distal (>10kb) Multiome 914
chr17:8,288,100–8,289,230 147.1 kb Distal (>10kb) Multiome 751
chr17:8,295,073–8,296,021 140.4 kb Distal (>10kb) Multiome 739
chr17:8,310,033–8,310,555 125.6 kb Distal (>10kb) Multiome 98
chr17:8,313,329–8,313,824 122.3 kb Distal (>10kb) Multiome 30
chr17:8,376,215–8,376,918 59.2 kb Distal (>10kb) Multiome 888
chr17:8,382,925–8,384,028 52.5 kb Distal (>10kb) Multiome 981
chr17:8,435,307–8,436,885 8 bp At TSS Multiome 847
chr17:8,584,054–8,584,700 148.5 kb Distal (>10kb) Multiome 18
chr17:8,629,690–8,631,825 195.2 kb Distal (>10kb) Multiome 878
chr17:8,745,813–8,746,432 310.2 kb Distal (>10kb) Multiome HiCAR 522

Genome Browser

Genomic view of the NDEL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr17:8,128,425 – 8,756,432
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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