This gene encodes a subunit of the condensin complex, which is responsible for the condensation and stabilization of chromosomes during mitosis and meiosis. Phosphorylation of the encoded protein activates the condensin complex. There are pseudogenes for this gene on chromosomes 8 and 15. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Transcription factors with Perturb-seq knockdown data for NCAPG. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NCAPG upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NCAPG, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:17,511,108–17,512,753 | 298.8 kb | Distal (>10kb) Multiome | 724 | |
| chr4:17,576,452–17,578,383 | 233.7 kb | Distal (>10kb) Multiome | 874 | |
| chr4:17,613,634–17,615,353 | 196.4 kb | Distal (>10kb) Multiome | 740 | |
| chr4:17,636,469–17,637,277 | 174.0 kb | Distal (>10kb) Multiome | 322 | |
| chr4:17,780,838–17,782,239 | 29.3 kb | Distal (>10kb) Multiome | 374 | |
| chr4:17,808,589–17,809,005 | 2.0 kb | Proximal (<10kb) | 170 | |
| chr4:17,810,219–17,811,664 | 126 bp | At TSS Multiome | 935 | |
| chr4:17,817,167–17,817,310 | 6.2 kb | Proximal (<10kb) | 77 | |
| chr4:18,020,217–18,023,062 | 211.0 kb | Distal (>10kb) Multiome | 967 |
Genomic view of the NCAPG locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.