Condensin complexes I and II play essential roles in mitotic chromosome assembly and segregation. Both condensins contain 2 invariant structural maintenance of chromosome (SMC) subunits, SMC2 (MIM 605576) and SMC4 (MIM 605575), but they contain different sets of non-SMC subunits. NCAPD3 is 1 of 3 non-SMC subunits that define condensin II (Ono et al., 2003 [PubMed 14532007]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for NCAPD3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NCAPD3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NCAPD3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:133,947,207–133,947,600 | 276.6 kb | Distal (>10kb) Multiome | 204 | |
| chr11:133,951,064–133,952,093 | 272.4 kb | Distal (>10kb) Multiome | 268 | |
| chr11:133,955,545–133,957,834 | 266.9 kb | Distal (>10kb) Multiome | 423 | |
| chr11:134,033,701–134,034,640 | 189.8 kb | Distal (>10kb) Multiome | 251 | |
| chr11:134,036,538–134,037,918 | 186.7 kb | Distal (>10kb) Multiome | 381 | |
| chr11:134,068,849–134,069,824 | 154.8 kb | Distal (>10kb) Multiome | 407 | |
| chr11:134,223,679–134,225,624 | 664 bp | At TSS Multiome | 944 | |
| chr11:134,252,809–134,254,050 | 29.5 kb | Distal (>10kb) Multiome | 758 | |
| chr11:134,272,860–134,273,509 | 49.2 kb | Distal (>10kb) Multiome | 183 | |
| chr11:134,275,655–134,277,823 | 52.5 kb | Distal (>10kb) Multiome | 418 | |
| chr11:134,331,384–134,332,745 | 107.9 kb | Distal (>10kb) Multiome | 483 | |
| chr11:134,360,067–134,360,637 | 136.5 kb | Distal (>10kb) Multiome | 397 | |
| chr11:134,411,283–134,413,029 | 188.3 kb | Distal (>10kb) Multiome | 258 |
Genomic view of the NCAPD3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.