This gene encodes a member of the neuron navigator gene family, which may play a role in cellular growth and migration. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Transcription factors with Perturb-seq knockdown data for NAV2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NAV2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NAV2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:19,564,063–19,564,859 | 213.5 kb | Distal (>10kb) Multiome HiCAR | 314 | |
| chr11:19,711,943–19,713,785 | 65.1 kb | Distal (>10kb) Multiome | 777 | |
| chr11:19,772,537–19,772,824 | 5.0 kb | Proximal (<10kb) | 86 | |
| chr11:19,776,766–19,778,034 | 631 bp | At TSS Multiome | 286 | |
| chr11:19,816,874–19,818,169 | 39.6 kb | Distal (>10kb) Multiome | 180 | |
| chr11:19,999,938–20,001,198 | 222.9 kb | Distal (>10kb) Multiome | 494 | |
| chr11:20,022,535–20,023,393 | 245.2 kb | Distal (>10kb) Multiome | 407 | |
| chr11:20,026,863–20,027,934 | 249.7 kb | Distal (>10kb) Multiome | 391 |
Genomic view of the NAV2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.