Transcription factors with Perturb-seq knockdown data for NATD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NATD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NATD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:20,992,594–20,993,594 | 260.3 kb | Distal (>10kb) Multiome | 237 | |
| chr17:21,041,818–21,044,206 | 210.1 kb | Distal (>10kb) Multiome | 1019 | |
| chr17:21,098,970–21,099,982 | 154.1 kb | Distal (>10kb) Multiome | 514 | |
| chr17:21,106,347–21,107,024 | 146.8 kb | Distal (>10kb) Multiome | 32 | |
| chr17:21,108,710–21,109,234 | 144.5 kb | Distal (>10kb) Multiome | 13 | |
| chr17:21,126,572–21,127,535 | 126.4 kb | Distal (>10kb) Multiome | 707 | |
| chr17:21,213,670–21,215,538 | 39.0 kb | Distal (>10kb) Multiome | 849 | |
| chr17:21,252,548–21,253,969 | 8 bp | At TSS Multiome | 558 | |
| chr17:21,255,389–21,255,820 | 2.0 kb | Proximal (<10kb) | 77 | |
| chr17:21,275,381–21,276,434 | 22.5 kb | Distal (>10kb) Multiome | 671 | |
| chr17:21,280,014–21,280,480 | 26.8 kb | Distal (>10kb) Multiome | 435 | |
| chr17:21,283,767–21,285,795 | 31.2 kb | Distal (>10kb) Multiome | 672 | |
| chr17:21,322,850–21,323,584 | 69.7 kb | Distal (>10kb) Multiome | 172 | |
| chr17:21,376,013–21,377,629 | 123.2 kb | Distal (>10kb) Multiome | 253 | |
| chr17:21,456,975–21,457,864 | 203.8 kb | Distal (>10kb) Multiome | 423 | |
| chr17:21,511,340–21,512,139 | 258.3 kb | Distal (>10kb) Multiome | 291 |
Genomic view of the NATD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.