This gene encodes a H1 histone binding protein that is involved in transporting histones into the nucleus of dividing cells. Multiple isoforms are encoded by transcript variants of this gene. The somatic form is expressed in all mitotic cells, is localized to the nucleus, and is coupled to the cell cycle. The testicular form is expressed in embryonic tissues, tumor cells, and the testis. In male germ cells, this protein is localized to the cytoplasm of primary spermatocytes, the nucleus of spermatids, and the periacrosomal region of mature spermatozoa. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for NASP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NASP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NASP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:45,303,203–45,304,881 | 280.2 kb | Distal (>10kb) Multiome | 1034 | |
| chr1:45,315,837–45,316,870 | 267.9 kb | Distal (>10kb) Multiome | 113 | |
| chr1:45,317,165–45,317,643 | 266.6 kb | Distal (>10kb) Multiome | 7 | |
| chr1:45,321,623–45,322,180 | 262.2 kb | Distal (>10kb) Multiome | 54 | |
| chr1:45,326,327–45,328,092 | 257.1 kb | Distal (>10kb) Multiome | 382 | |
| chr1:45,339,505–45,340,694 | 243.9 kb | Distal (>10kb) Multiome | 951 | |
| chr1:45,490,605–45,491,773 | 92.7 kb | Distal (>10kb) Multiome | 900 | |
| chr1:45,499,499–45,500,620 | 83.8 kb | Distal (>10kb) Multiome | 831 | |
| chr1:45,521,163–45,522,604 | 62.0 kb | Distal (>10kb) Multiome | 1155 | |
| chr1:45,550,427–45,551,304 | 33.1 kb | Distal (>10kb) Multiome | 1006 | |
| chr1:45,583,145–45,585,182 | 744 bp | At TSS Multiome | 997 | |
| chr1:45,622,461–45,623,374 | 39.1 kb | Distal (>10kb) Multiome | 169 | |
| chr1:45,686,052–45,687,740 | 103.1 kb | Distal (>10kb) Multiome | 1015 | |
| chr1:45,687,860–45,688,505 | 104.4 kb | Distal (>10kb) Multiome | 861 | |
| chr1:45,750,186–45,751,093 | 166.7 kb | Distal (>10kb) Multiome | 961 | |
| chr1:45,802,824–45,804,412 | 219.6 kb | Distal (>10kb) Multiome | 753 |
Genomic view of the NASP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.