This gene encodes a member of the nucleosome assembly protein (NAP) family. This protein participates in DNA replication and may play a role in modulating chromatin formation and contribute to the regulation of cell proliferation. Alternative splicing results in multiple transcript variants encoding different isoforms; however, not all have been fully described. [provided by RefSeq, Apr 2015]
Transcription factors with Perturb-seq knockdown data for NAP1L1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NAP1L1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NAP1L1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:75,511,106–75,512,100 | 573.0 kb | Distal (>10kb) Multiome HiCAR | 945 | |
| chr12:75,779,687–75,780,741 | 304.4 kb | Distal (>10kb) Multiome | 288 | |
| chr12:75,892,478–75,893,385 | 191.8 kb | Distal (>10kb) Multiome | 414 | |
| chr12:76,029,985–76,033,119 | 53.1 kb | Distal (>10kb) Multiome | 1086 | |
| chr12:76,040,352–76,040,839 | 8.9 kb | Proximal (<10kb) | 27 | |
| chr12:76,055,490–76,055,680 | 5.8 kb | Proximal (<10kb) | 46 | |
| chr12:76,080,873–76,081,055 | 3.7 kb | Proximal (<10kb) | 40 | |
| chr12:76,083,403–76,085,384 | 82 bp | At TSS Multiome | 931 | |
| chr12:76,092,418–76,092,810 | 7.7 kb | Proximal (<10kb) | 65 | |
| chr12:76,347,962–76,348,990 | 263.7 kb | Distal (>10kb) Multiome HiCAR | 838 | |
| chr12:76,371,854–76,372,495 | 287.5 kb | Distal (>10kb) Multiome | 65 | |
| chr12:76,384,502–76,385,032 | 300.0 kb | Distal (>10kb) Multiome | 65 |
Genomic view of the NAP1L1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.